Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library

BACKGROUND: Casein kinase 2 (CK2) is dysregulated in various human cancers and is a promising target for cancer therapy. To date, there is no small molecular CK2 inhibitor in clinical trial yet. With the aim to identify novel CK2 inhibitors, we screened a natural product library. METHODS: We adopted...

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Detalles Bibliográficos
Autores principales: Hung, Ming-Szu, Xu, Zhidong, Lin, Yu-Ching, Mao, Jian-Hua, Yang, Cheng-Ta, Chang, Pey-Jium, Jablons, David M, You, Liang
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696466/
https://www.ncbi.nlm.nih.gov/pubmed/19419583
http://dx.doi.org/10.1186/1471-2407-9-135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696466/
https://www.ncbi.nlm.nih.gov/pubmed/19419583
http://dx.doi.org/10.1186/1471-2407-9-135

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