Cargando…

Thermostabilisation of the neurotensin receptor NTS1

Structural studies on G protein-coupled receptors (GPCRs) have been hampered for many years by their instability in detergent solution and by the number of potential conformations that receptors can adopt. Recently, the structures of the β(1) and β(2) adrenergic receptors and the adenosine A(2a) rec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shibata, Yoko, White, Jim F., Serrano-Vega, Maria J., Magnani, Francesca, Aloia, Amanda L., Grisshammer, Reinhard, Tate, Christopher G.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696590/ https://www.ncbi.nlm.nih.gov/pubmed/19422831 http://dx.doi.org/10.1016/j.jmb.2009.04.068

Ejemplares similares

Stability of the Neurotensin Receptor NTS1 Free in Detergent Solution and Immobilized to Affinity Resin
por: White, Jim F., et al.
Publicado: (2010)

Transient and Stable Expression of the Neurotensin Receptor NTS1: A Comparison of the Baculovirus-Insect Cell and the T-REx-293 Expression Systems
por: Xiao, Su, et al.
Publicado: (2013)

Structure of the agonist-bound neurotensin receptor
por: White, Jim F., et al.
Publicado: (2012)

Structural Dynamics and Thermostabilization of Neurotensin Receptor 1
por: Lee, Sangbae, et al.
Publicado: (2015)

Structural prerequisites for G-protein activation by the neurotensin receptor
por: Krumm, Brian E., et al.
Publicado: (2015)

Structure and dynamics of a constitutively active neurotensin receptor
por: Krumm, Brian E., et al.
Publicado: (2016)

Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyr[11]neurotensin
por: Rouibi, Khalil, et al.
Publicado: (2015)

Thermostabilisation of the Serotonin Transporter in a Cocaine-Bound Conformation
por: Abdul-Hussein, Saba, et al.
Publicado: (2013)

Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS(1))
por: Bumbak, Fabian, et al.
Publicado: (2023)

Thermostabilisation of an Agonist-Bound Conformation of the Human Adenosine A(2A) Receptor
por: Lebon, Guillaume, et al.
Publicado: (2011)

G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro
por: Inagaki, Sayaka, et al.
Publicado: (2015)

Conformational thermostabilisation of corticotropin releasing factor receptor 1
por: Kean, James, et al.
Publicado: (2015)

Thermostabilisation System of VEPP-5 Preinjector.
por: Gubin, K V, et al.
Publicado: (1999)

Neurotensin analogs by fluoroglycosylation at N(ω)-carbamoylated arginines for PET imaging of NTS1-positive tumors
por: Schindler, Lisa, et al.
Publicado: (2022)

Insightful Backbone Modifications Preventing Proteolytic Degradation of Neurotensin Analogs Improve NTS1-Induced Protective Hypothermia
por: Previti, Santo, et al.
Publicado: (2020)

Development of a Neurotensin-Derived (68)Ga-Labeled PET Ligand with High In Vivo Stability for Imaging of NTS(1) Receptor-Expressing Tumors
por: Schindler, Lisa, et al.
Publicado: (2022)

The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor
por: Baker, Jillian G., et al.
Publicado: (2011)

Rational thermostabilisation of four-helix bundle dimeric de novo proteins
por: Irumagawa, Shin, et al.
Publicado: (2021)

Potency of a thermostabilised chimpanzee adenovirus Rift Valley Fever vaccine in cattle
por: Dulal, Pawan, et al.
Publicado: (2016)

Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib
por: Younes, Mohamad, et al.
Publicado: (2014)

Intermittent Hypoxia Up-Regulates Gene Expressions of Peptide YY (PYY), Glucagon-like Peptide-1 (GLP-1), and Neurotensin (NTS) in Enteroendocrine Cells
por: Shobatake, Ryogo, et al.
Publicado: (2019)

Dynamic Behavior of the Active and Inactive States of the Adenosine A(2A) Receptor
por: Lee, Sangbae, et al.
Publicado: (2014)

Imaging Neurotensin Receptor in Prostate Cancer With (64)Cu-Labeled Neurotensin Analogs
por: Deng, Huaifu, et al.
Publicado: (2017)

Rapid Computational Prediction of Thermostabilizing Mutations for G Protein-Coupled Receptors
por: Bhattacharya, Supriyo, et al.
Publicado: (2014)

Neurotensin receptors in pancreatic ductal carcinomas
por: Körner, Meike, et al.
Publicado: (2015)

Endogenous CNS Expression of Neurotensin and Neurotensin Receptors Is Altered during the Postpartum Period in Outbred Mice
por: Driessen, Terri M., et al.
Publicado: (2014)

A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties
por: Lee, Hee-Kyoung, et al.
Publicado: (2015)

Design, Synthesis, and Biological Evaluation of the First Radio-Metalated Neurotensin Analogue Targeting Neurotensin Receptor 2
por: Bodin, Sacha, et al.
Publicado: (2023)

Translation, adaptation, and validation of the MeNTS score in colombian population: The MeNTS Col score
por: Torregrosa, Lilian, et al.
Publicado: (2023)

Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS
por: Spaziano, Giuseppe, et al.
Publicado: (2015)

A Review of the Role of Neurotensin and Its Receptors in Colorectal Cancer
por: Qiu, Shengyang, et al.
Publicado: (2017)

Neurotensin and its receptors in the control of glucose homeostasis
por: Mazella, Jean, et al.
Publicado: (2012)

Differential allosteric modulation within dopamine D(2)R - neurotensin NTS1R and D(2)R - serotonin 5-HT(2A)R receptor complexes gives bias to intracellular calcium signalling
por: Plach, Michael, et al.
Publicado: (2019)

The role of Neurotensin and its receptors in non-gastrointestinal cancers: a review
por: Nikolaou, Stella, et al.
Publicado: (2020)

Peptide ligand recognition by G protein-coupled receptors
por: Krumm, Brian E., et al.
Publicado: (2015)

Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity
por: Roussy, Geneviève, et al.
Publicado: (2009)

Botulinum Neurotoxins (BoNTs)—Antibody and Vaccine
por: Lou, Jianlong, et al.
Publicado: (2018)

Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin
por: Law, Ivy Ka Man, et al.
Publicado: (2016)

Neurotensin receptor 1 immunoreactivity in the peripheral ganglia and carotid body
por: Porzionato, A., et al.
Publicado: (2009)

Cannabinoid CB(1) Receptors Mediate the Gastroprotective Effect of Neurotensin
por: Hassanzadeh, Parichehr, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_f0klh8adjcs4dk8km8vnj6kq8o