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Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors
BACKGROUND: Huntington’s disease is caused by expansion of a polyglutamine tract found in the amino-terminal of the ubiquitously expressed protein huntingtin. Well studied in its mutant form, huntingtin has a wide variety of normal functions, loss of which may also contribute to disease progression....
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BMJ Publishing Group
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696822/ https://www.ncbi.nlm.nih.gov/pubmed/19451134 http://dx.doi.org/10.1136/jmg.2009.066399 |