Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59

The unique species specificity of the bacterial cytolysin intermedilysin is explained by its requirement for the human complement regulator CD59 as the primary receptor. Binding studies using individual domains of intermedilysin mapped the CD59-binding site to domain 4 and swap mutants between human...

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Detalles Bibliográficos
Autores principales: Hughes, Timothy R., Ross, Kirsty S., Cowan, Graeme J.M., Sivasankar, Baalasubramanian, Harris, Claire L., Mitchell, Timothy J., Morgan, B. Paul
Formato: Texto
Lenguaje:English
Publicado: Pergamon Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697320/
https://www.ncbi.nlm.nih.gov/pubmed/19200600
http://dx.doi.org/10.1016/j.molimm.2009.01.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697320/
https://www.ncbi.nlm.nih.gov/pubmed/19200600
http://dx.doi.org/10.1016/j.molimm.2009.01.003

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