Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase

Dense deposit disease (DDD) is strongly associated with the uncontrolled activation of the complement alternative pathway. Factor H (CFH)-deficient (Cfh(−/−)) mice spontaneously develop C3 deposition along the glomerular basement membrane (GBM) with subsequent development of glomerulonephritis with...

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Detalles Bibliográficos
Autores principales: Paixão-Cavalcante, Danielle, Hanson, Steven, Botto, Marina, Cook, H. Terence, Pickering, Matthew C.
Formato: Texto
Lenguaje:English
Publicado: Pergamon Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697322/
https://www.ncbi.nlm.nih.gov/pubmed/19411110
http://dx.doi.org/10.1016/j.molimm.2009.03.030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697322/
https://www.ncbi.nlm.nih.gov/pubmed/19411110
http://dx.doi.org/10.1016/j.molimm.2009.03.030

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