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Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase
Dense deposit disease (DDD) is strongly associated with the uncontrolled activation of the complement alternative pathway. Factor H (CFH)-deficient (Cfh(−/−)) mice spontaneously develop C3 deposition along the glomerular basement membrane (GBM) with subsequent development of glomerulonephritis with...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Pergamon Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697322/ https://www.ncbi.nlm.nih.gov/pubmed/19411110 http://dx.doi.org/10.1016/j.molimm.2009.03.030 |