Tbx1 Regulates the BMP-Smad1 Pathway in a Transcription Independent Manner

Tbx1 is a T-box transcription factor implicated in DiGeorge syndrome. The molecular function of Tbx1 is unclear although it can transactivate reporters with T-box binding elements. We discovered that Tbx1 binds Smad1 and suppresses the Bmp4/Smad1 signaling. Tbx1 interferes with Smad1 to Smad4 bindin...

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Detalles Bibliográficos
Autores principales: Fulcoli, F. Gabriella, Huynh, Tuong, Scambler, Peter J., Baldini, Antonio
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698216/
https://www.ncbi.nlm.nih.gov/pubmed/19557177
http://dx.doi.org/10.1371/journal.pone.0006049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698216/
https://www.ncbi.nlm.nih.gov/pubmed/19557177
http://dx.doi.org/10.1371/journal.pone.0006049

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