Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor

HLA-A*6801 exhibits several unusual features. First, it is known to bind weakly to CD8 due to the presence of an A245V substitution in the α3 domain. Second, it is able to accommodate unusually long peptides as a result of peptide ‘kinking’ in the binding groove. Third, CD8(+) cytotoxic T lymphocyte...

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Detalles Bibliográficos
Autores principales: Gostick, Emma, Cole, David K, Hutchinson, Sarah L, Wooldridge, Linda, Tafuro, Sabrina, Laugel, Bruno, Lissina, Anna, Oxenius, Annette, Boulter, Jonathan M, Price, David A, Sewell, Andrew K
Formato: Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2007
Materias:
Molecular immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699040/
https://www.ncbi.nlm.nih.gov/pubmed/17273992
http://dx.doi.org/10.1002/eji.200636243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699040/
https://www.ncbi.nlm.nih.gov/pubmed/17273992
http://dx.doi.org/10.1002/eji.200636243

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