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Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor
HLA-A*6801 exhibits several unusual features. First, it is known to bind weakly to CD8 due to the presence of an A245V substitution in the α3 domain. Second, it is able to accommodate unusually long peptides as a result of peptide ‘kinking’ in the binding groove. Third, CD8(+) cytotoxic T lymphocyte...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699040/ https://www.ncbi.nlm.nih.gov/pubmed/17273992 http://dx.doi.org/10.1002/eji.200636243 |