Fluorescence changes reveal kinetic steps of muscarinic receptor–mediated modulation of phosphoinositides and Kv7.2/7.3 K(+) channels

G protein–coupled receptors initiate signaling cascades. M(1) muscarinic receptor (M(1)R) activation couples through Gα(q) to stimulate phospholipase C (PLC), which cleaves phosphatidylinositol 4,5-bisphosphate (PIP(2)). Depletion of PIP(2) closes PIP(2)-requiring Kv7.2/7.3 potassium channels (M cur...

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Detalles Bibliográficos
Autores principales: Jensen, Jill B., Lyssand, John S., Hague, Chris, Hille, Bertil
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699104/
https://www.ncbi.nlm.nih.gov/pubmed/19332618
http://dx.doi.org/10.1085/jgp.200810075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699104/
https://www.ncbi.nlm.nih.gov/pubmed/19332618
http://dx.doi.org/10.1085/jgp.200810075

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