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Fluorescence changes reveal kinetic steps of muscarinic receptor–mediated modulation of phosphoinositides and Kv7.2/7.3 K(+) channels

G protein–coupled receptors initiate signaling cascades. M(1) muscarinic receptor (M(1)R) activation couples through Gα(q) to stimulate phospholipase C (PLC), which cleaves phosphatidylinositol 4,5-bisphosphate (PIP(2)). Depletion of PIP(2) closes PIP(2)-requiring Kv7.2/7.3 potassium channels (M cur...

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Detalles Bibliográficos
Autores principales:	Jensen, Jill B., Lyssand, John S., Hague, Chris, Hille, Bertil
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699104/ https://www.ncbi.nlm.nih.gov/pubmed/19332618 http://dx.doi.org/10.1085/jgp.200810075

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