Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

Lack of immunological tolerance against self-antigens results in autoimmune disorders. During onset of autoimmunity, dendritic cells (DCs) are thought to be critical for priming of self-reactive T cells that have escaped tolerance induction. However, because DCs can also induce T cell tolerance, it...

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Detalles Bibliográficos
Autores principales: Ohnmacht, Caspar, Pullner, Andrea, King, Susan B.S., Drexler, Ingo, Meier, Stefanie, Brocker, Thomas, Voehringer, David
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699126/
https://www.ncbi.nlm.nih.gov/pubmed/19237601
http://dx.doi.org/10.1084/jem.20082394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699126/
https://www.ncbi.nlm.nih.gov/pubmed/19237601
http://dx.doi.org/10.1084/jem.20082394

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