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The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells

We have addressed the role of the inducible costimulator (ICOS) in the development of T cell help for B cells and in the generation, survival and reactivation of memory CD4 T cells and B cells. We find that while T cell help for all antibody isotypes (including IgG2c) is impaired in ICOS knockout (I...

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Detalles Bibliográficos
Autores principales:	Mahajan, Simmi, Cervera, Ana, MacLeod, Megan, Fillatreau, Simon, Perona-Wright, Georgia, Meek, Stephen, Smith, Andrew, MacDonald, Andrew, Gray, David
Formato:	Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2007
Materias:	Cellular immune response
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699381/ https://www.ncbi.nlm.nih.gov/pubmed/17549732 http://dx.doi.org/10.1002/eji.200636661

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