Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates

In acute inflammation, extracellular ATP activates P2X(7) ion channel receptors (P2X(7)R) on M1 polarized macrophages to release pro-inflammatory IL-1β through activation of the caspase-1/nucleotide-binding domain and leucine-rich repeat receptor containing pyrin domain 3 (NLRP3) inflammasome. In co...

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Detalles Bibliográficos
Autores principales: Pelegrin, Pablo, Surprenant, Annmarie
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699392/
https://www.ncbi.nlm.nih.gov/pubmed/19536133
http://dx.doi.org/10.1038/emboj.2009.163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699392/
https://www.ncbi.nlm.nih.gov/pubmed/19536133
http://dx.doi.org/10.1038/emboj.2009.163

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