Targeted Deletion of Multiple CTCF-Binding Elements in the Human C-MYC Gene Reveals a Requirement for CTCF in C-MYC Expression

BACKGROUND: Insulators and domain boundaries both shield genes from adjacent enhancers and inhibit intrusion of heterochromatin into transgenes. Previous studies examined the functional mechanism of the MYC insulator element MINE and its CTCF binding sites in the context of transgenes that were rand...

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Detalles Bibliográficos
Autores principales: Gombert, Wendy M., Krumm, Anton
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699473/
https://www.ncbi.nlm.nih.gov/pubmed/19568426
http://dx.doi.org/10.1371/journal.pone.0006109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699473/
https://www.ncbi.nlm.nih.gov/pubmed/19568426
http://dx.doi.org/10.1371/journal.pone.0006109

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