Targeted correction of a thalassemia-associated β-globin mutation induced by pseudo-complementary peptide nucleic acids

β-Thalassemia is a genetic disorder caused by mutations in the β-globin gene. Triplex-forming oligonucleotides and triplex-forming peptide nucleic acids (PNAs) have been shown to stimulate recombination in mammalian cells via site-specific binding and creation of altered helical structures that prov...

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Detalles Bibliográficos
Autores principales: Lonkar, Pallavi, Kim, Ki-Hyun, Kuan, Jean Y., Chin, Joanna Y., Rogers, Faye A., Knauert, Melissa P., Kole, Ryszard, Nielsen, Peter E., Glazer, Peter M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699504/
https://www.ncbi.nlm.nih.gov/pubmed/19364810
http://dx.doi.org/10.1093/nar/gkp217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699504/
https://www.ncbi.nlm.nih.gov/pubmed/19364810
http://dx.doi.org/10.1093/nar/gkp217

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