A genotype-to-phenotype map of in vitro selected RNA-cleaving DNAzymes: implications for accessing the target phenotype

Herein, we describe a case study into the population dynamics of in vitro selection, using RNA-cleaving DNAzymes as a model system. We sought to understand how the composition of the population can change over time in response to different levels of selection pressure, and how well these changes are...

Descripción completa

Detalles Bibliográficos
Autores principales: Schlosser, Kenny, Lam, Jeffrey C. F., Li, Yingfu
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699508/
https://www.ncbi.nlm.nih.gov/pubmed/19357090
http://dx.doi.org/10.1093/nar/gkp222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699508/
https://www.ncbi.nlm.nih.gov/pubmed/19357090
http://dx.doi.org/10.1093/nar/gkp222

Ejemplares similares