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Utility of tolcapone in fluctuating Parkinson’s disease

Fluctuating Parkinson’s disease (PD) represents a clinical management challenge. The primary utility of levodopa in patients with PD is moderated by the “wearing off” phenomena seen with long-term use. COMT inhibitors slow down the rapid metabolism of levodopa, resulting in a more-sustained response...

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Detalles Bibliográficos
Autores principales: Stocchi, Fabrizio, De Pandis, Maria Francesca
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699640/
https://www.ncbi.nlm.nih.gov/pubmed/18046910