Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study

PURPOSE: To compare the efficacy of brinzolamide in Japanese patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH) after a change from timolol in combination therapy with latanoprost. METHODS: A 12-week, prospective, open-label, comparative study was performed in 20 patients [...

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Autores principales: Ishikawa, Shusaku, Nakamura, Yoshimi, Nakamura, Yuko, Sakai, Hiroshi, Sawaguchi, Shoichi, Terashima, Kazuo, Kanno, Makoto, Yamashita, Hidetoshi
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699801/
https://www.ncbi.nlm.nih.gov/pubmed/19668419
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author Ishikawa, Shusaku
Nakamura, Yoshimi
Nakamura, Yuko
Sakai, Hiroshi
Sawaguchi, Shoichi
Terashima, Kazuo
Kanno, Makoto
Yamashita, Hidetoshi
author_facet Ishikawa, Shusaku
Nakamura, Yoshimi
Nakamura, Yuko
Sakai, Hiroshi
Sawaguchi, Shoichi
Terashima, Kazuo
Kanno, Makoto
Yamashita, Hidetoshi
author_sort Ishikawa, Shusaku
collection PubMed
description PURPOSE: To compare the efficacy of brinzolamide in Japanese patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH) after a change from timolol in combination therapy with latanoprost. METHODS: A 12-week, prospective, open-label, comparative study was performed in 20 patients [11 males and 9 females, mean age of 64.5 ± 11.0 (SD)y] with POAG or OH treated with both latanoprost once daily and timolol 0.5% twice daily. During the study brinzolamide was substituted for timolol. Intraocular pressure (IOP) was measured at baseline, 4, 8, and 12 weeks. Blood pressure (BP), pulse rate (PR), and adverse events were also recorded. RESULTS: IOPs at baseline, 4, 8, and 12 weeks were 18.6 ± 2.1 mmHg, 17.8 ± 2.6 mmHg, 17.4 ± 2.5 mmHg, and 17.3 ± 3.5 mmHg, respectively. IOP reduction at 4 and 8 weeks was statistically significant (p < 0.05). The PR was significantly increased at 12 weeks (p < 0.01), but BP was not significantly affected. Four ocular adverse events were noted, but all were mild and transient. CONCLUSIONS: Substituting brinzolamide 1% for timolol 0.5% in combination therapy with latanoprost 0.005% demonstrated significant IOP reduction with improvement in PR with POAG or OH. Combination therapy using latanoprost and brinzolamide may be recommended for better IOP control with fewer systemic adverse events.
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spelling pubmed-26998012009-08-10 Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study Ishikawa, Shusaku Nakamura, Yoshimi Nakamura, Yuko Sakai, Hiroshi Sawaguchi, Shoichi Terashima, Kazuo Kanno, Makoto Yamashita, Hidetoshi Clin Ophthalmol Original Research PURPOSE: To compare the efficacy of brinzolamide in Japanese patients with primary open-angle glaucoma (POAG) or ocular hypertension (OH) after a change from timolol in combination therapy with latanoprost. METHODS: A 12-week, prospective, open-label, comparative study was performed in 20 patients [11 males and 9 females, mean age of 64.5 ± 11.0 (SD)y] with POAG or OH treated with both latanoprost once daily and timolol 0.5% twice daily. During the study brinzolamide was substituted for timolol. Intraocular pressure (IOP) was measured at baseline, 4, 8, and 12 weeks. Blood pressure (BP), pulse rate (PR), and adverse events were also recorded. RESULTS: IOPs at baseline, 4, 8, and 12 weeks were 18.6 ± 2.1 mmHg, 17.8 ± 2.6 mmHg, 17.4 ± 2.5 mmHg, and 17.3 ± 3.5 mmHg, respectively. IOP reduction at 4 and 8 weeks was statistically significant (p < 0.05). The PR was significantly increased at 12 weeks (p < 0.01), but BP was not significantly affected. Four ocular adverse events were noted, but all were mild and transient. CONCLUSIONS: Substituting brinzolamide 1% for timolol 0.5% in combination therapy with latanoprost 0.005% demonstrated significant IOP reduction with improvement in PR with POAG or OH. Combination therapy using latanoprost and brinzolamide may be recommended for better IOP control with fewer systemic adverse events. Dove Medical Press 2008-12 2008-12 /pmc/articles/PMC2699801/ /pubmed/19668419 Text en © 2008 Ishikawa et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Ishikawa, Shusaku
Nakamura, Yoshimi
Nakamura, Yuko
Sakai, Hiroshi
Sawaguchi, Shoichi
Terashima, Kazuo
Kanno, Makoto
Yamashita, Hidetoshi
Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study
title Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study
title_full Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study
title_fullStr Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study
title_full_unstemmed Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study
title_short Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study
title_sort efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699801/
https://www.ncbi.nlm.nih.gov/pubmed/19668419
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