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Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q

OBJECTIVE: Linkage of the chromosome 1q21–25 region to type 2 diabetes has been demonstrated in multiple ethnic groups. We performed common variant fine-mapping across a 23-Mb interval in a multiethnic sample to search for variants responsible for this linkage signal. RESEARCH DESIGN AND METHODS: In...

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Detalles Bibliográficos
Autores principales: Prokopenko, Inga, Zeggini, Eleftheria, Hanson, Robert L., Mitchell, Braxton D., Rayner, N. William, Akan, Pelin, Baier, Leslie, Das, Swapan K., Elliott, Katherine S., Fu, Mao, Frayling, Timothy M., Groves, Christopher J., Gwilliam, Rhian, Scott, Laura J., Voight, Benjamin F., Hattersley, Andrew T., Hu, Cheng, Morris, Andrew D., Ng, Maggie, Palmer, Colin N.A., Tello-Ruiz, Marcela, Vaxillaire, Martine, Wang, Cong-rong, Stein, Lincoln, Chan, Juliana, Jia, Weiping, Froguel, Philippe, Elbein, Steven C., Deloukas, Panos, Bogardus, Clifton, Shuldiner, Alan R., McCarthy, Mark I.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699860/
https://www.ncbi.nlm.nih.gov/pubmed/19389826
http://dx.doi.org/10.2337/db09-0081