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Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes: Interactions With Metformin

OBJECTIVE: We sought to establish the extent and mechanisms by which sitagliptin and metformin singly and in combination modify islet disease progression in human islet amyloid polypeptide transgenic (HIP) rats, a model for type 2 diabetes. RESEARCH DESIGN AND METHODS: HIP rats were treated with sit...

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Detalles Bibliográficos
Autores principales:	Matveyenko, Aleksey V., Dry, Sarah, Cox, Heather I., Moshtaghian, Artemis, Gurlo, Tatyana, Galasso, Ryan, Butler, Alexandra E., Butler, Peter C.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699878/ https://www.ncbi.nlm.nih.gov/pubmed/19403868 http://dx.doi.org/10.2337/db09-0058

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