Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor

BACKGROUND: Wee1 is a tyrosine kinase regulating S-G2 cell cycle transition through the inactivating phosphorylation of CDC2. The inhibition of Wee1 kinase by a selective small molecule inhibitor significantly enhances the anti-tumor efficacy of DNA damaging agents, specifically in p53 negative tumo...

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Detalles Bibliográficos
Autores principales: Mizuarai, Shinji, Yamanaka, Kazunori, Itadani, Hiraku, Arai, Tsuyoshi, Nishibata, Toshihide, Hirai, Hiroshi, Kotani, Hidehito
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700070/
https://www.ncbi.nlm.nih.gov/pubmed/19500427
http://dx.doi.org/10.1186/1476-4598-8-34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700070/
https://www.ncbi.nlm.nih.gov/pubmed/19500427
http://dx.doi.org/10.1186/1476-4598-8-34

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