A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen

BACKGROUND: Regulators of G protein signaling (RGSs) accelerate GTP hydrolysis by Gα subunits and profoundly inhibit signaling by G protein-coupled receptors (GPCRs). The distinct expression patterns and pathophysiologic regulation of RGS proteins suggest that inhibitors may have therapeutic potenti...

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Detalles Bibliográficos
Autores principales: Roof, Rebecca A, Roman, David L, Clements, Samuel T, Sobczyk-Kojiro, Katarzyna, Blazer, Levi L, Ota, Shodai, Mosberg, Henry I, Neubig, Richard R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700083/
https://www.ncbi.nlm.nih.gov/pubmed/19463173
http://dx.doi.org/10.1186/1471-2210-9-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700083/
https://www.ncbi.nlm.nih.gov/pubmed/19463173
http://dx.doi.org/10.1186/1471-2210-9-9

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