The Ups and Downs of Mutation Frequencies during Aging Can Account for the Apert Syndrome Paternal Age Effect

Apert syndrome is almost always caused by a spontaneous mutation of paternal origin in one of two nucleotides in the fibroblast growth factor receptor 2 gene (FGFR2). The incidence of this disease increases with the age of the father (paternal age effect), and this increase is greater than what woul...

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Detalles Bibliográficos
Autores principales: Yoon, Song-Ro, Qin, Jian, Glaser, Rivka L., Wang Jabs, Ethylin, Wexler, Nancy S., Sokol, Rebecca, Arnheim, Norman, Calabrese, Peter
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700275/
https://www.ncbi.nlm.nih.gov/pubmed/19593369
http://dx.doi.org/10.1371/journal.pgen.1000558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700275/
https://www.ncbi.nlm.nih.gov/pubmed/19593369
http://dx.doi.org/10.1371/journal.pgen.1000558

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