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The Ups and Downs of Mutation Frequencies during Aging Can Account for the Apert Syndrome Paternal Age Effect
Apert syndrome is almost always caused by a spontaneous mutation of paternal origin in one of two nucleotides in the fibroblast growth factor receptor 2 gene (FGFR2). The incidence of this disease increases with the age of the father (paternal age effect), and this increase is greater than what woul...
Autores principales: | Yoon, Song-Ro, Qin, Jian, Glaser, Rivka L., Wang Jabs, Ethylin, Wexler, Nancy S., Sokol, Rebecca, Arnheim, Norman, Calabrese, Peter |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700275/ https://www.ncbi.nlm.nih.gov/pubmed/19593369 http://dx.doi.org/10.1371/journal.pgen.1000558 |
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