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Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation
Alzheimer's disease is an age-dependent neurodegenerative disorder that is characterized by a progressive decline in cognitive function. γ-secretase dysfunction is evident in many cases of early onset familial Alzheimer's disease. However, the mechanism by which γ-secretase dysfunction res...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700400/ https://www.ncbi.nlm.nih.gov/pubmed/19414612 http://dx.doi.org/10.1083/jcb.200809151 |