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Two structurally distinct domains of the nucleoporin Nup170 cooperate to tether a subset of nucleoporins to nuclear pores

How individual nucleoporins (Nups) perform their role in nuclear pore structure and function is largely unknown. In this study, we examined the structure of purified Nup170 to obtain clues about its function. We show that Nup170 adopts a crescent moon shape with two structurally distinct and separab...

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Detalles Bibliográficos
Autores principales: Flemming, Dirk, Sarges, Phillip, Stelter, Philipp, Hellwig, Andrea, Böttcher, Bettina, Hurt, Ed
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700402/
https://www.ncbi.nlm.nih.gov/pubmed/19414606
http://dx.doi.org/10.1083/jcb.200810016