Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors

The Ras/MAPK pathway is critical for human development and plays a central role in the formation and progression of most cancers. Children born with germ-line mutations in BRAF, MEK1 or MEK2 develop cardio-facio-cutaneous (CFC) syndrome, an autosomal dominant syndrome characterized by a distinctive...

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Detalles Bibliográficos
Autores principales: Anastasaki, Corina, Estep, Anne L., Marais, Richard, Rauen, Katherine A., Patton, E. Elizabeth
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701326/
https://www.ncbi.nlm.nih.gov/pubmed/19376813
http://dx.doi.org/10.1093/hmg/ddp186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701326/
https://www.ncbi.nlm.nih.gov/pubmed/19376813
http://dx.doi.org/10.1093/hmg/ddp186

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