Inhibition of RhoA pathway rescues the endocytosis defects in Oligophrenin1 mouse model of mental retardation

The patho-physiological hypothesis of mental retardation caused by the deficiency of the RhoGAP Oligophrenin1 (OPHN1), relies on the well-known functions of Rho GTPases on neuronal morphology, i.e. dendritic spine structure. Here, we describe a new function of this Bin/Amphiphysin/Rvs domain contain...

Descripción completa

Detalles Bibliográficos
Autores principales: Khelfaoui, Malik, Pavlowsky, Alice, Powell, Andrew D., Valnegri, Pamela, Cheong, Kenneth W., Blandin, Yann, Passafaro, Maria, Jefferys, John G.R., Chelly, Jamel, Billuart, Pierre
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701329/
https://www.ncbi.nlm.nih.gov/pubmed/19401298
http://dx.doi.org/10.1093/hmg/ddp189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701329/
https://www.ncbi.nlm.nih.gov/pubmed/19401298
http://dx.doi.org/10.1093/hmg/ddp189

Ejemplares similares