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Inhibition of RhoA pathway rescues the endocytosis defects in Oligophrenin1 mouse model of mental retardation
The patho-physiological hypothesis of mental retardation caused by the deficiency of the RhoGAP Oligophrenin1 (OPHN1), relies on the well-known functions of Rho GTPases on neuronal morphology, i.e. dendritic spine structure. Here, we describe a new function of this Bin/Amphiphysin/Rvs domain contain...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701329/ https://www.ncbi.nlm.nih.gov/pubmed/19401298 http://dx.doi.org/10.1093/hmg/ddp189 |