Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis

The phosphatidylinositol 3-kinase (PI3K)/AKT pathway is frequently upregulated in human cancer. Activation of this pathway has been reported to be associated with resistance to various chemotherapeutical agents. We here used a chemical biology/chemical informatic approach to identify apoptotic mecha...

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Detalles Bibliográficos
Autores principales: Berndtsson, Maria, Hernlund, Emma, Shoshan, Maria C., Linder, Stig
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701489/
https://www.ncbi.nlm.nih.gov/pubmed/19568785
http://dx.doi.org/10.1007/s12154-009-0017-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701489/
https://www.ncbi.nlm.nih.gov/pubmed/19568785
http://dx.doi.org/10.1007/s12154-009-0017-7

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