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Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis
The phosphatidylinositol 3-kinase (PI3K)/AKT pathway is frequently upregulated in human cancer. Activation of this pathway has been reported to be associated with resistance to various chemotherapeutical agents. We here used a chemical biology/chemical informatic approach to identify apoptotic mecha...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701489/ https://www.ncbi.nlm.nih.gov/pubmed/19568785 http://dx.doi.org/10.1007/s12154-009-0017-7 |