In thrombin stimulated human platelets Citalopram, Promethazine, Risperidone, and Ziprasidone, but not Diazepam, may exert their pharmacological effects also through intercalation in membrane phospholipids in a receptor-independent manner

Intercalation of drugs in the platelet membrane affects phospholipid-requiring enzymatic processes according to the drugs’ intercalation capability. We investigated effects of Promethazine, Citalopram, Ziprasidone, Risperidone, and Diazepam on phospholipase A(2) (PLA(2)) and polyphosphoinositide (PP...

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Detalles Bibliográficos
Autores principales: Oruch, Ramadhan, Hodneland, Erlend, Pryme, Ian F., Holmsen, Holm
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701490/
https://www.ncbi.nlm.nih.gov/pubmed/19568786
http://dx.doi.org/10.1007/s12154-009-0018-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701490/
https://www.ncbi.nlm.nih.gov/pubmed/19568786
http://dx.doi.org/10.1007/s12154-009-0018-6

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