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Inherent Dynamics of the Acid-Sensing Ion Channel 1 Correlates with the Gating Mechanism
The acid-sensing ion channel 1 (ASIC1) is a key receptor for extracellular protons. Although numerous structural and functional studies have been performed on this channel, the structural dynamics underlying the gating mechanism remains unknown. We used normal mode analysis, mutagenesis, and electro...
| Główni autorzy: | , , , , , , |
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| Format: | Texto |
| Język: | English |
| Wydane: |
Public Library of Science
2009
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| Hasła przedmiotowe: | |
| Dostęp online: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701601/ https://www.ncbi.nlm.nih.gov/pubmed/19597538 http://dx.doi.org/10.1371/journal.pbio.1000151 |