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Inherent Dynamics of the Acid-Sensing Ion Channel 1 Correlates with the Gating Mechanism

The acid-sensing ion channel 1 (ASIC1) is a key receptor for extracellular protons. Although numerous structural and functional studies have been performed on this channel, the structural dynamics underlying the gating mechanism remains unknown. We used normal mode analysis, mutagenesis, and electro...

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Detalles Bibliográficos
Autores principales:	Yang, Huaiyu, Yu, Ye, Li, Wei-Guang, Yu, Fang, Cao, Hui, Xu, Tian-Le, Jiang, Hualiang
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701601/ https://www.ncbi.nlm.nih.gov/pubmed/19597538 http://dx.doi.org/10.1371/journal.pbio.1000151

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