HDAC1 and HDAC2 Regulate Oligodendrocyte Differentiation By Disrupting β-Catenin-TCF Interaction

Oligodendrocyte development is regulated by the interplay of repressors and activators in a complex transcriptional network. Here we report that two histone-modifying enzymes, HDAC1 and HDAC2, are required for oligodendrocyte formation. Genetic deletion of both HDAC1 and HDAC2 in oligodendrocyte lin...

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Detalles Bibliográficos
Autores principales: Ye, Feng, Chen, Ying, Hoang, ThaoNguyen, Montgomery, Rusty L., Zhao, Xian-hui, Bu, Hong, Hu, Tom, Taketo, Makoto M., van Es, Johan H., Clevers, Hans, Hsieh, Jenny, Bassel-Duby, Rhonda, Olson, Eric N., Lu, Q. Richard
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701973/
https://www.ncbi.nlm.nih.gov/pubmed/19503085
http://dx.doi.org/10.1038/nn.2333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701973/
https://www.ncbi.nlm.nih.gov/pubmed/19503085
http://dx.doi.org/10.1038/nn.2333

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