Functional Analysis of -351 Interleukin-9 Promoter Polymorphism Reveals an Activator Controlled by NF-κB

Genetic studies have shown linkages for asthma to the chromosomal region 5q31-q33 in humans that includes the IL-9 gene. An A-to-G base substitution has been identified at bp -351 in the IL-9 promoter. The role of this polymorphism in IL-9 promoter function was assessed utilizing CD4+ T cells purifi...

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Detalles Bibliográficos
Autores principales: Early, S Brandon, Huyett, Phillip, Brown-Steinke, Kathleen, Borish, Larry, Steinke, John W.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702712/
https://www.ncbi.nlm.nih.gov/pubmed/19387455
http://dx.doi.org/10.1038/gene.2009.28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702712/
https://www.ncbi.nlm.nih.gov/pubmed/19387455
http://dx.doi.org/10.1038/gene.2009.28

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