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Functional Analysis of -351 Interleukin-9 Promoter Polymorphism Reveals an Activator Controlled by NF-κB
Genetic studies have shown linkages for asthma to the chromosomal region 5q31-q33 in humans that includes the IL-9 gene. An A-to-G base substitution has been identified at bp -351 in the IL-9 promoter. The role of this polymorphism in IL-9 promoter function was assessed utilizing CD4+ T cells purifi...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702712/ https://www.ncbi.nlm.nih.gov/pubmed/19387455 http://dx.doi.org/10.1038/gene.2009.28 |