Defects in tRNA Modification Associated with Neurological and Developmental Dysfunctions in Caenorhabditis elegans Elongator Mutants

Elongator is a six subunit protein complex, conserved from yeast to humans. Mutations in the human Elongator homologue, hELP1, are associated with the neurological disease familial dysautonomia. However, how Elongator functions in metazoans, and how the human mutations affect neural functions is inc...

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Detalles Bibliográficos
Autores principales: Chen, Changchun, Tuck, Simon, Byström, Anders S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702823/
https://www.ncbi.nlm.nih.gov/pubmed/19593383
http://dx.doi.org/10.1371/journal.pgen.1000561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702823/
https://www.ncbi.nlm.nih.gov/pubmed/19593383
http://dx.doi.org/10.1371/journal.pgen.1000561

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