Identification of non-muscle myosin heavy chain as a substrate for Cdk5 and tool for drug screening

BACKGROUND: Deregulated activation of cyclin-dependent kinase-5 (Cdk5) is implicated in neurodegenerative disorders such as Alzheimer's disease. One of the restricting factors for developing specific Cdk5 inhibitors is the lack of reproducible and well-characterized cellular in vitro assay syst...

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Detalles Bibliográficos
Autores principales: Jämsä, Anne, Agerman, Karin, Radesäter, Ann-Cathrin, Ottervald, Jan, Malmström, Jonas, Hiller, Gösta, Liu, Gang, Vasänge, Mervi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703631/
https://www.ncbi.nlm.nih.gov/pubmed/19534817
http://dx.doi.org/10.1186/1423-0127-16-55

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703631/
https://www.ncbi.nlm.nih.gov/pubmed/19534817
http://dx.doi.org/10.1186/1423-0127-16-55

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