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Identification of non-muscle myosin heavy chain as a substrate for Cdk5 and tool for drug screening
BACKGROUND: Deregulated activation of cyclin-dependent kinase-5 (Cdk5) is implicated in neurodegenerative disorders such as Alzheimer's disease. One of the restricting factors for developing specific Cdk5 inhibitors is the lack of reproducible and well-characterized cellular in vitro assay syst...
Autores principales: | Jämsä, Anne, Agerman, Karin, Radesäter, Ann-Cathrin, Ottervald, Jan, Malmström, Jonas, Hiller, Gösta, Liu, Gang, Vasänge, Mervi |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703631/ https://www.ncbi.nlm.nih.gov/pubmed/19534817 http://dx.doi.org/10.1186/1423-0127-16-55 |
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