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The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells

BACKGROUND: Cationic antimicrobial peptides (CAPs) with antitumor activity constitute a promising group of novel anticancer agents. These peptides induce lysis of cancer cells through interactions with the plasma membrane. It is not known which cancer cell membrane components influence their suscept...

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Detalles Bibliográficos
Autores principales: Fadnes, Bodil, Rekdal, Øystein, Uhlin-Hansen, Lars
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703650/
https://www.ncbi.nlm.nih.gov/pubmed/19527490
http://dx.doi.org/10.1186/1471-2407-9-183