Cargando…

CCL2 Accelerates Microglia-Mediated Aβ Oligomer Formation and Progression of Neurocognitive Dysfunction

BACKGROUND: The linkages between neuroinflammation and Alzheimer's disease (AD) pathogenesis are well established. What is not, however, is how specific immune pathways and proteins affect the disease. To this end, we previously demonstrated that transgenic over-expression of CCL2 enhanced micr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kiyota, Tomomi, Yamamoto, Masaru, Xiong, Huangui, Lambert, Mary P., Klein, William L., Gendelman, Howard E., Ransohoff, Richard M., Ikezu, Tsuneya
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703798/ https://www.ncbi.nlm.nih.gov/pubmed/19593388 http://dx.doi.org/10.1371/journal.pone.0006197

Ejemplares similares

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
por: Clayton, Kevin, et al.
Publicado: (2021)

Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
por: Clayton, Kevin, et al.
Publicado: (2021)

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy
por: Clayton, Kevin A., et al.
Publicado: (2017)

Integrated Expression Profiles of mRNA and miRNA in Polarized Primary Murine Microglia
por: Freilich, Robert W., et al.
Publicado: (2013)

AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice
por: Kiyota, Tomomi, et al.
Publicado: (2011)

Using mechanical homogenization to isolate microglia from mouse brain tissue to preserve transcriptomic integrity
por: Herron, Shawn, et al.
Publicado: (2022)

Tau-tubulin kinase
por: Ikezu, Seiko, et al.
Publicado: (2014)

Oligodendrocyte Injury and Pathogenesis of HIV-1-Associated Neurocognitive Disorders
por: Liu, Han, et al.
Publicado: (2016)

Direct contacts of microglia on myelin sheath and Ranvier’s node in the corpus callosum in rats
por: Zhang, Jingdong, et al.
Publicado: (2019)

Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia
por: Ruan, Zhi, et al.
Publicado: (2022)

TIA1 regulates the generation and response to toxic tau oligomers
por: Jiang, Lulu, et al.
Publicado: (2018)

Telomere Length Shortening in Microglia: Implication for Accelerated Senescence and Neurocognitive Deficits in HIV
por: Hsiao, Chiu-Bin, et al.
Publicado: (2021)

Minocycline attenuation of rat corpus callosum abnormality mediated by low-dose lipopolysaccharide-induced microglia activation
por: Zhang, Jingdong, et al.
Publicado: (2021)

Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer’s Disease Mouse Models
por: Muraoka, Satoshi, et al.
Publicado: (2021)

Syk and Yea Shall Find
por: Wolozin, Benjamin, et al.
Publicado: (2015)

Corrigendum to “Syk and ye shall find” [EBioMedicine 2 (11) (2015) 190-1591]
por: Wolozin, Benjamin, et al.
Publicado: (2016)

Astrocyte Dysfunctions and HIV-1 Neurotoxicity
por: Ton, Hoai, et al.
Publicado: (2013)

The Role of Microglia in Perioperative Neurocognitive Disorders
por: Fan, Wenguo, et al.
Publicado: (2020)

Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice
por: Yukawa, Kayo, et al.
Publicado: (2023)

Real-Time Imaging and Quantification of Amyloid-β Peptide Aggregates by Novel Quantum-Dot Nanoprobes
por: Tokuraku, Kiyotaka, et al.
Publicado: (2009)

The Role of Microglia in Perioperative Neuroinflammation and Neurocognitive Disorders
por: Saxena, Sarah, et al.
Publicado: (2021)

Methamphetamine augments HIV-1 gp120 inhibition of synaptic transmission and plasticity in rat hippocampal slices: Implications for methamphetamine exacerbation of HIV-associated neurocognitive disorders
por: Zheng, Ya, et al.
Publicado: (2022)

Crosstalk Between Astrocytes and Microglia: An Overview
por: Matejuk, Agata, et al.
Publicado: (2020)

Microglia activation mediated by toll-like receptor-4 impairs brain white matter tracts in rats
por: Yang, Xinglong, et al.
Publicado: (2018)

Microglia display modest phagocytic capacity for extracellular tau oligomers
por: Majerova, Petra, et al.
Publicado: (2014)

Microglial WNT5A supports dendritic spines maturation and neuronal firing
por: Yeh, Hana, et al.
Publicado: (2023)

Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study
por: Muraoka, Satoshi, et al.
Publicado: (2020)

Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models
por: Ikezu, Seiko, et al.
Publicado: (2020)

Neuritogenic function of microglia in maternal immune activation and autism spectrum disorders
por: Kalavai, Srinidhi Venkatesan, et al.
Publicado: (2020)

HIV and Neurocognitive Dysfunction
por: Spudich, Serena
Publicado: (2013)

Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia
por: Sondag, Cindy M, et al.
Publicado: (2009)

Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia
por: Das, Rashmi, et al.
Publicado: (2020)

Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease
por: Embury, Christine M, et al.
Publicado: (2016)

Microglia: The Real Foe in HIV-1-Associated Neurocognitive Disorders?
por: Borrajo López, Ana, et al.
Publicado: (2021)

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons
por: Ruan, Zhi, et al.
Publicado: (2020)

Severer nodular lesion in white matter than in gray matter in simian immunodeficiency virus-infected monkey, but not closely correlated with viral infection
por: Zhang, Jingdong, et al.
Publicado: (2020)

CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy
por: Cherry, Jonathan D., et al.
Publicado: (2020)

Neurocognitive dysfunction in mood disorders
por: Moore, Brian P., et al.
Publicado: (2003)

CCL2 is required for initiation but not persistence of HIV infection mediated neurocognitive disease in mice
por: Kim, Boe-Hyun, et al.
Publicado: (2023)

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice
por: Ruan, Zhi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qng2hcro45dpjtjsgdhqus1hll