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α-ENaC is a functional element of the hypertonicity-induced cation channel in HepG2 cells and it mediates proliferation

The molecular correlate of hypertonicity-induced cation channels (HICCs) and their role in proliferation vs. apoptosis is a matter of debate. We report in this paper that, in whole-cell patch-clamp recordings, hypertonic stress (340→450 mosM) reversibly increased the Na(+) conductance of HepG2 cells...

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Detalles Bibliográficos
Autores principales: Bondarava, Maryna, Li, Tongju, Endl, Elmar, Wehner, Frank
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704294/
https://www.ncbi.nlm.nih.gov/pubmed/19241091
http://dx.doi.org/10.1007/s00424-009-0649-z