Olfactory behavior and physiology are disrupted in prion protein knockout mice

The prion protein PrP(C) is infamous for its role in disease, yet its normal physiological function remains unknown. Here we report a novel behavioral phenotype of PrP(−/−) mice in an odor-guided task. This phenotype is manifest in three PrP knockout lines on different genetic backgrounds, strong ev...

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Detalles Bibliográficos
Autores principales: Le Pichon, Claire E., Valley, Matthew T., Polymenidou, Magdalini, Chesler, Alexander T., Sagdullaev, Botir T., Aguzzi, Adriano, Firestein, Stuart
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704296/
https://www.ncbi.nlm.nih.gov/pubmed/19098904
http://dx.doi.org/10.1038/nn.2238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704296/
https://www.ncbi.nlm.nih.gov/pubmed/19098904
http://dx.doi.org/10.1038/nn.2238

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