Cargando…

The Effects of γ-Aminobutyric Acid, Vinegar, and Dried Bonito on Blood Pressure in Normotensive and Mildly or Moderately Hypertensive Volunteers

The purpose of this study was to examine the effects of γ-aminobutyric acid (GABA) in fermented drinking water prepared from sodium glutamate, vinegar, and dried bonito (FDWG) compared with placebo [vinegar and dried bonito without GABA (FDW)] and its safety in normotensive and mildly or moderately...

Descripción completa

Detalles Bibliográficos
Autores principales: Tanaka, Hiroko, Watanabe, Kenichi, Ma, Meilei, Hirayama, Masao, Kobayashi, Takashi, Oyama, Hiroshi, Sakaguchi, Yoshiko, Kanda, Mitsuo, Kodama, Makoto, Aizawa, Yoshifusa
Formato: Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704332/
https://www.ncbi.nlm.nih.gov/pubmed/19590713
http://dx.doi.org/10.3164/jcbn.09-04
_version_ 1782168927903678464
author Tanaka, Hiroko
Watanabe, Kenichi
Ma, Meilei
Hirayama, Masao
Kobayashi, Takashi
Oyama, Hiroshi
Sakaguchi, Yoshiko
Kanda, Mitsuo
Kodama, Makoto
Aizawa, Yoshifusa
author_facet Tanaka, Hiroko
Watanabe, Kenichi
Ma, Meilei
Hirayama, Masao
Kobayashi, Takashi
Oyama, Hiroshi
Sakaguchi, Yoshiko
Kanda, Mitsuo
Kodama, Makoto
Aizawa, Yoshifusa
author_sort Tanaka, Hiroko
collection PubMed
description The purpose of this study was to examine the effects of γ-aminobutyric acid (GABA) in fermented drinking water prepared from sodium glutamate, vinegar, and dried bonito (FDWG) compared with placebo [vinegar and dried bonito without GABA (FDW)] and its safety in normotensive and mildly or moderately hypertensive volunteers. A double-blind, placebo-controlled, randomized study was conducted involving volunteers with normal (group-N) and mildly or moderately high (group-H) blood pressure (BP). After a pretreatment period of 2 weeks (weeks –2), the subjects received FDWG or FDW for 12 weeks followed by 4 weeks of no intake (weeks 16). In group-H, both FDWG and FDW significantly decreased systolic (SBP, −7.6 ± 4.0 and −5.5 ± 1.5 mmHg, p<0.05, respectively) and diastolic (DBP, −10.6 ± 4.0 and −7.6 ± 1.7 mmHg, p<0.01, respectively) BP compared to the baseline (0-week) value at 12 weeks, respectively. There were no abnormal changes in hematological or blood chemistry variables, urinalysis, heart rate, or body weight in the study groups. These findings indicated that vinegar and dried bonito with or without GABA might have an effect on BP in mildly or moderately hypertensive patients.
format Text
id pubmed-2704332
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher the Society for Free Radical Research Japan
record_format MEDLINE/PubMed
spelling pubmed-27043322009-07-09 The Effects of γ-Aminobutyric Acid, Vinegar, and Dried Bonito on Blood Pressure in Normotensive and Mildly or Moderately Hypertensive Volunteers Tanaka, Hiroko Watanabe, Kenichi Ma, Meilei Hirayama, Masao Kobayashi, Takashi Oyama, Hiroshi Sakaguchi, Yoshiko Kanda, Mitsuo Kodama, Makoto Aizawa, Yoshifusa J Clin Biochem Nutr Original Article The purpose of this study was to examine the effects of γ-aminobutyric acid (GABA) in fermented drinking water prepared from sodium glutamate, vinegar, and dried bonito (FDWG) compared with placebo [vinegar and dried bonito without GABA (FDW)] and its safety in normotensive and mildly or moderately hypertensive volunteers. A double-blind, placebo-controlled, randomized study was conducted involving volunteers with normal (group-N) and mildly or moderately high (group-H) blood pressure (BP). After a pretreatment period of 2 weeks (weeks –2), the subjects received FDWG or FDW for 12 weeks followed by 4 weeks of no intake (weeks 16). In group-H, both FDWG and FDW significantly decreased systolic (SBP, −7.6 ± 4.0 and −5.5 ± 1.5 mmHg, p<0.05, respectively) and diastolic (DBP, −10.6 ± 4.0 and −7.6 ± 1.7 mmHg, p<0.01, respectively) BP compared to the baseline (0-week) value at 12 weeks, respectively. There were no abnormal changes in hematological or blood chemistry variables, urinalysis, heart rate, or body weight in the study groups. These findings indicated that vinegar and dried bonito with or without GABA might have an effect on BP in mildly or moderately hypertensive patients. the Society for Free Radical Research Japan 2009-07 2009-06-30 /pmc/articles/PMC2704332/ /pubmed/19590713 http://dx.doi.org/10.3164/jcbn.09-04 Text en Copyright © 2009 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Tanaka, Hiroko
Watanabe, Kenichi
Ma, Meilei
Hirayama, Masao
Kobayashi, Takashi
Oyama, Hiroshi
Sakaguchi, Yoshiko
Kanda, Mitsuo
Kodama, Makoto
Aizawa, Yoshifusa
The Effects of γ-Aminobutyric Acid, Vinegar, and Dried Bonito on Blood Pressure in Normotensive and Mildly or Moderately Hypertensive Volunteers
title The Effects of γ-Aminobutyric Acid, Vinegar, and Dried Bonito on Blood Pressure in Normotensive and Mildly or Moderately Hypertensive Volunteers
title_full The Effects of γ-Aminobutyric Acid, Vinegar, and Dried Bonito on Blood Pressure in Normotensive and Mildly or Moderately Hypertensive Volunteers
title_fullStr The Effects of γ-Aminobutyric Acid, Vinegar, and Dried Bonito on Blood Pressure in Normotensive and Mildly or Moderately Hypertensive Volunteers
title_full_unstemmed The Effects of γ-Aminobutyric Acid, Vinegar, and Dried Bonito on Blood Pressure in Normotensive and Mildly or Moderately Hypertensive Volunteers
title_short The Effects of γ-Aminobutyric Acid, Vinegar, and Dried Bonito on Blood Pressure in Normotensive and Mildly or Moderately Hypertensive Volunteers
title_sort effects of γ-aminobutyric acid, vinegar, and dried bonito on blood pressure in normotensive and mildly or moderately hypertensive volunteers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704332/
https://www.ncbi.nlm.nih.gov/pubmed/19590713
http://dx.doi.org/10.3164/jcbn.09-04
work_keys_str_mv AT tanakahiroko theeffectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT watanabekenichi theeffectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT mameilei theeffectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT hirayamamasao theeffectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT kobayashitakashi theeffectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT oyamahiroshi theeffectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT sakaguchiyoshiko theeffectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT kandamitsuo theeffectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT kodamamakoto theeffectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT aizawayoshifusa theeffectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT tanakahiroko effectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT watanabekenichi effectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT mameilei effectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT hirayamamasao effectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT kobayashitakashi effectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT oyamahiroshi effectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT sakaguchiyoshiko effectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT kandamitsuo effectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT kodamamakoto effectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers
AT aizawayoshifusa effectsofgaminobutyricacidvinegaranddriedbonitoonbloodpressureinnormotensiveandmildlyormoderatelyhypertensivevolunteers