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Exploration of the One-Bead One-Compound Methodology for the Design of Prolyl Oligopeptidase Substrates
Here we describe the design, synthesis and evaluation of the first solid-phase substrates for prolyl oligopeptidase (POP), a cytosolic serine peptidase associated with schizophrenia, bipolar affective disorder and related neuropsychiatric disorders. This study seeks to contribute to the future desig...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704865/ https://www.ncbi.nlm.nih.gov/pubmed/19593439 http://dx.doi.org/10.1371/journal.pone.0006222 |