Glucagon-Like Peptide-1 Induced Signaling and Insulin Secretion Do Not Drive Fuel and Energy Metabolism in Primary Rodent Pancreatic β-Cells

BACKGROUND: Glucagon like peptide-1 (GLP-1) and its analogue exendin-4 (Ex-4) enhance glucose stimulated insulin secretion (GSIS) and activate various signaling pathways in pancreatic β-cells, in particular cAMP, Ca(2+) and protein kinase-B (PKB/Akt). In many cells these signals activate intermediar...

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Detalles Bibliográficos
Autores principales: Peyot, Marie-Line, Gray, Joshua P., Lamontagne, Julien, Smith, Peter J. S., Holz, George G., Madiraju, S. R. Murthy, Prentki, Marc, Heart, Emma
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704866/
https://www.ncbi.nlm.nih.gov/pubmed/19593440
http://dx.doi.org/10.1371/journal.pone.0006221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704866/
https://www.ncbi.nlm.nih.gov/pubmed/19593440
http://dx.doi.org/10.1371/journal.pone.0006221

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