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Ryanodine receptor-mediated arrhythmias and sudden cardiac death

The cardiac ryanodine receptor-Ca(2+) release channel (RyR2) is an essential sarcoplasmic reticulum (SR) transmembrane protein that plays a central role in excitation–contraction coupling (ECC) in cardiomyocytes. Aberrant spontaneous, diastolic Ca(2+) leak from the SR due to dysfunctional RyR2 contr...

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Detalles Bibliográficos
Autores principales: Blayney, Lynda M., Lai, F. Anthony
Formato: Texto
Lenguaje:English
Publicado: Pergamon Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704947/
https://www.ncbi.nlm.nih.gov/pubmed/19345240
http://dx.doi.org/10.1016/j.pharmthera.2009.03.006