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Modeling the Repertoire of True Tumor-Specific MHC I Epitopes in a Human Tumor
DNA replication has a finite measurable error rate, net of repair, in all cells. Clonal proliferation of cancer cells leads therefore to accumulation of random mutations. A proportion of these mutational events can create new immunogenic epitopes that, if processed and presented by an MHC allele, ma...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704956/ https://www.ncbi.nlm.nih.gov/pubmed/19593447 http://dx.doi.org/10.1371/journal.pone.0006094 |